Studies on the Membrane Proteins of H. pylori

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The membrane proteins (MPs) of H. pylori (especially adhesins) are essential for colonization, survival, pathogenesis, and cause inflammatory responses. Ace Infectious provides research services on H. pylori MPs to help discover vaccine development solutions and drug therapy targets.

The MPs of H. pylori are well worth studying. The MPs of H. pylori play an important role in its survival in the stomach. For example, the adhesion properties of the adhesin BabA vary with pH, which allows H. pylori to survive by adapting to gastric pH changes and adhering to gastric cells at the right time. Then, the MPs of H. pylori are also associated with the pathogenicity of H. pylori and causing inflammatory responses. SabA-positive Western strains of H. pylori can cause intestinal metaplasia, gastric cancer, and corpuscular atrophy. Deletion of AlpA and AlpB in H. pylori East Asian strains reduces IL-8 secretion. What’s more, various pore proteins in the cell membrane of H. pylori have a role in the physiological homeostasis and resistance to antibiotics.

Learn more:H. pylori MP Studies

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